Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis.
Haruki Sada, Hiroyuki Egi, Kentaro Ide, Hiroyuki Sawada, Yusuke Sumi, Minoru Hattori, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan · Surgery today · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established. Peritoneal lavage with hydrogen-rich saline significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Peritoneal lavage with hydrogen-rich saline significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure.
What the Researchers Studied
The authors reviewed oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established.
What Effects Did Molecular Hydrogen Have?
Peritoneal lavage with hydrogen-rich saline significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure. The authors concluded that this procedure can improve survival after sepsis through mitigating the sepsis-induced organ failure by inhibiting oxidative stress, apoptosis, and inflammatory pathways.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.