Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis.
Haruki Sada, Hiroyuki Egi, Kentaro Ide, Hiroyuki Sawada, Yusuke Sumi, Minoru Hattori, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan · Surgery today · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established. Peritoneal lavage with HRS significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
Oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established.
Main Findings Across the Literature
Peritoneal lavage with HRS significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure.
Authors’ Conclusion
The authors concluded that this procedure can improve survival after sepsis through mitigating the sepsis-induced organ failure by inhibiting oxidative stress, apoptosis, and inflammatory pathways.