Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping.
Shan-Wen Lui, Ting-Yu Hsieh, Jeng-Wei Lu, Yi-Jung Ho, Feng-Cheng Liu · APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
Neutral Summary
In this laboratory study, the authors report that However, its immunomodulatory effects remain insufficiently defined.
Study Design and Population
An additional 15 untreated RA patients served as controls for the assessment of MHAT-induced changes in lymphocyte profiles and type 1 regulatory T (Tr1) cells.
Sample size: 25
Hydrogen Intervention
Other or not reported
Additional Notes
H2HUBB TAKEAWAY
In this laboratory study, the authors report that However, its immunomodulatory effects remain insufficiently defined.
What the Researchers Studied
Source-reported study description: Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are characterized by immune dysregulation that leads to chronic inflammation and organ damage.
Source-reported study description: Current therapeutic strategies-including corticosteroids, immunosuppressants, and biologics-often exhibit variable efficacy and are associated with potential adverse effects.
What the Study Found
The authors reported: Molecular hydrogen, recognized for its ability to scavenge mitochondrial reactive oxygen species and inhibit the NLRP3 inflammasome, has emerged as a promising adjunctive treatment.
What the Findings Mean
The authors concluded/reported: However, its immunomodulatory effects remain insufficiently defined.
Hydrogen Dose and Delivery
Normalized molecular-hydrogen equivalent: 8.50 mg H₂ from 170 mg hydrogen-enriched coral calcium using the H2HUBB 20:1 Ca-equivalent rule.
Study Details
Publication type: laboratory_study
Evidence source level: B_ABSTRACT
Original scholarly source: https://pubmed.ncbi.nlm.nih.gov/40590161/