Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
Jinghu He, Shaohu Xiong, Jianquan Zhang, Junwu Wang, Aijun Sun, Xiang Mei, Xuejun Sun, Chuansen Zhang, Qiang Wang · The Journal of surgical research · 2013
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Independent study record
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H2HUBB TAKEAWAY
In rats, treatment with hydrogen-rich saline reduced the weight loss and diarrhea and alleviated the colonic mucosal damage in the UC rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The present study aimed to investigate the effects of hydrogen on UC using a rat model.
How Molecular Hydrogen Was Used
Hydrogen was supplied through intraperitoneal injection of 10 or 20 mL/kg hydrogen-rich saline.
What the Researchers Found
Treatment with hydrogen-rich saline reduced the weight loss and diarrhea and alleviated the colonic mucosal damage in the UC rats.
Biological or Mechanistic Findings
Antioxidative hydrogen-rich saline effectively protected the rats from UC, which might be, at least in part, because of inhibition of vascular endothelial growth factor. Antioxidative hydrogen-rich saline effectively protected the rats from UC, which might be, at least in part, because of inhibition of vascular endothelial growth factor.
Authors’ Conclusion
The authors concluded that antioxidative hydrogen-rich saline effectively protected the rats from UC, which might be, at least in part, because of inhibition of vascular endothelial growth factor. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.