Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
Jing-Yao Zhang, Qi-Fei Wu, Yong Wan, Si-Dong Song, Jia Xu, Xin-Sen Xu, Hu-Lin Chang, Ming-Hui Tai, Ya-Feng Dong, Chang Liu · World journal of gastroenterology · 2014
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Independent study record
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H2HUBB TAKEAWAY
In rats, the oxidative stress levels of MDA and MPO in the gastric tissues increased significantly in the aspirin-treated group compared with the HRW group (2.43 ± 0.145 vs 1.79 ± 0.116 nmol/mg prot, P < 0.05 and 2.53 ± 0.238 vs 1.40 ± 0.208 U/g tissue, P < 0.05, respectively). These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
To investigate the role of the hydrogen-rich water (HRW) in the prevention of aspirin-induced gastric mucosal injury in rats.
How Molecular Hydrogen Was Used
Hydrogen-rich water
What the Researchers Found
The oxidative stress levels of MDA and MPO in the gastric tissues increased significantly in the aspirin-treated group compared with the HRW group (2.43 ± 0.145 vs 1.79 ± 0.116 nmol/mg prot, P < 0.05 and 2.53 ± 0.238 vs 1.40 ± 0.208 U/g tissue, P < 0.05, respectively).
Authors’ Conclusion
The authors concluded that HRW pretreatment alleviated the aspirin-induced gastric lesions by inhibiting the oxidative stress, inflammatory reaction and reducing the COX-2 in the gastric tissues. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.