Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson’s disease.
Anzu Suzuki, Mikako Ito, Tomonori Hamaguchi, Hiroshi Mori, Yuka Takeda, Ryuko Baba, Takeshi Watanabe, Ken Kurokawa, Susumu Asakawa, Masaaki Hirayama, Kinji Ohno · PloS one · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, among the seven representative bacteria that the researchers analyzed for hydrogen production, three bacterial groups/genera/species ( Blautia coccoides group, Clostridium leptum subgroup, and Bacteroides fragilis group) were decreased, whereas Lactobacillus was increased in PD [ 11 ]. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Among the seven representative bacteria that the researchers analyzed for hydrogen production, three bacterial groups/genera/species ( Blautia coccoides group, Clostridium leptum subgroup, and Bacteroides fragilis group) were decreased, whereas Lactobacillus was increased in PD [ 11 ].
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
10.1371/journal.pone.0208313.t001 Table 1 Bacterial strains used for quantification of hydrogen production and the culture medium. Hydrogen gas concentration was measured as previously described [ 25 ] with partial modifications. A fraction of the headspace gas (100 μl) was intermittently sampled using a gas-tight syringe, and the concentration of hydrogen was measured by a GC-7A gas chromatography equipped with thermal conductivity detector (TCD) (Shimadzu Scientific Instruments, Inc.). Among the seven representative bacteria that the researchers analyzed for hydrogen production, three bacterial groups/genera/species ( Blautia coccoides group, Clostridium leptum subgroup, and Bacteroides fragilis group) were decreased, whereas Lactobacillus was increased in PD [ 11 ]. Another possible mechanism is that hydrogen induces hormetic responses. Second, multiple reports point to the notion that hydrogen activates the Nrf2 signaling pathway [ 54 – 62 ].
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.