Research Progress of Molecular H2 in Mediating Immune Tolerance via Regulating Tregs-from the Perspective of the 2025 Nobel Prize in Physiology or Medicine.
Xiaolin Ding, Wenjie Tang, Yumei Wang, Jinfeng Tian, Jingfei Shi, Youzhen Wei, Chao Cui · Drug design, development and therapy · 2026
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
The review reports that Preliminary and accumulating studies suggest that H2 may protect Tregs' survival, enhance their proliferative activity and immunosuppressive function by inhibiting oxidative stress, regulating inflammatory signaling pathways (eg, NF-κB…
What the Researchers Studied
Source-reported study description: The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E.
Source-reported study description: Brunkow, Fred Ramsdell, and Shimon Sakaguchi in recognition of their pioneering contributions to the field of regulatory T cells (Tregs) and peripheral immune tolerance-defining Tregs as the core…
What the Study Found
The authors reported: As a novel bioactive molecule, molecular hydrogen (H2) possesses advantages of antioxidation, low toxicity, and multiple administration routes.
What the Findings Mean
The authors concluded/reported: Preliminary and accumulating studies suggest that H2 may protect Tregs' survival, enhance their proliferative activity and immunosuppressive function by inhibiting oxidative stress, regulating inflammatory signaling pathways (eg, NF-κB…
Study Details
Publication type: narrative_review
Evidence source level: B_ABSTRACT
Original scholarly source: https://pmc.ncbi.nlm.nih.gov/articles/PMC13525816/