Should hydrogen therapy be included in a musculoskeletal medicine routine?
Sergej M Ostojic · F1000Research · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Finally, the consumption of water containing a high concentration of H₂ (31% saturation) for up to 12 weeks improved surrogate markers of muscle pain and fatigability in 22 patients with inherited and acquired myopathies treated with low-dose prednisone 9. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Finally, the consumption of water containing a high concentration of H₂ (31% saturation) for up to 12 weeks improved surrogate markers of muscle pain and fatigability in 22 patients with inherited and acquired myopathies treated with low-dose prednisone 9.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 31% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 31% source-reported H₂ gas concentration; reported treatment duration: 14 days. Finally, the consumption of water containing a high concentration of H₂ (31% saturation) for up to 12 weeks improved surrogate markers of muscle pain and fatigability in 22 patients with inherited and acquired myopathies treated with low-dose prednisone 9. The authors concluded that based on the information provided by the H₂ gas-manufacturing company, as well as other information available to the FDA, the agency had no questions about the conclusion that hydrogen gas is GRAS under the intended conditions of use.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 40. The source-reported hydrogen concentration was 31% source-reported H₂ gas concentration. The reported treatment duration was 14 days.
Limitations and Safety
Reported limitations: Typically, these studies were designed as single-blind pilot trials, with small sample sizes (< 40 participants) and of short duration (≤ 12 weeks).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.