The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.
Zuzana Sumbalová, Jarmila Kucharská, Zuzana Rausová, Anna Gvozdjáková, Mária Szántová, Branislav Kura, Viliam Mojto, Ján Slezák · International journal of molecular sciences · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 30 patients with NAFLD and 15 healthy volunteers were included in this clinical trial, after 8 weeks of adjuvant therapy with HRW, the concentration of CoQ10 in platelets increased, plasma TBARS decreased, and the efficiency of OXPHOS improved, while in the P group, the changes were non-significant.
What the Researchers Studied
30 patients with NAFLD and 15 healthy volunteers were included in this clinical trial.
How the Study Was Conducted
Placebo-controlled human clinical trial.
How Molecular Hydrogen Was Used
A total of 17 patients (H₂ group) drank water three × 330 mL/day with tablets producing HRW (>4 mg/L H₂) for 8 weeks, and 13 patients (P group) drank water with placebo tablets producing CO₂.
What the Researchers Found
After 8 weeks of adjuvant therapy with HRW, the concentration of CoQ10 in platelets increased, plasma TBARS decreased, and the efficiency of OXPHOS improved, while in the P group, the changes were non-significant.