The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death.
Seokjin Haam, Sungsoo Lee, Hyo Chae Paik, Moo Suk Park, Joo Han Song, Beom Jin Lim, Atsunori Nakao · European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2015
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Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, the OC in the hydrogen group was higher than in the control group, but the difference was not statistically significant (P = 0.0862). The authors concluded that hydrogen gas inhalation during EVLP improved the function of DCD lungs, which may increase the utilization of DCD lungs. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In this study, the effect of hydrogen gas, a known antioxidant, was investigated on a DCD lung model during EVLP.
How Molecular Hydrogen Was Used
Ten pigs were randomized into either a control (n = 5) or a hydrogen group (n = 5). During EVLP, the lungs were ventilated with room air in the control group, and with 2% hydrogen gas in the hydrogen group.
What Molecular Hydrogen Changed
The OC in the hydrogen group was higher than in the control group, but the difference was not statistically significant (P = 0.0862).
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.