The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial.
Meng-Meng Shi, Yun-Tian Chen, Xiao-Dan Wang, Yun-Feng Zhang, Ting Cheng, Hui Chen, Feng Sun, Hong Bao, Rong Chen, Wei-Ning Xiong, Yuan-Lin Song, Qing-Yun Li, Jie-Ming Qu · Journal of clinical biochemistry and nutrition · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 64 patients with COVID-19, the present findings showed that hydrogen/oxygen inhalation shortened the virus shedding duration, decreased the inflammatory factor levels, as well as resolved the pulmonary lesions compared to oxygen inhalation alone, thereby reducing the occurrence of severe cases in the early stage. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 64 patients with COVID-19. The present findings showed that hydrogen/oxygen inhalation shortened the virus shedding duration, decreased the inflammatory factor levels, as well as resolved the pulmonary lesions compared to oxygen inhalation alone, thereby reducing the occurrence of severe cases in the early stage.
What the Researchers Studied
The researchers studied 64 patients with COVID-19. The study used a randomized human clinical trial.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 50% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 50% source-reported H₂ gas concentration; 3 L/min total gas flow (approximately 1500 mL/min H₂ component); via nasal cannula; H2HUBB estimated inhaled H₂ concentration: approximately 5.0–6.7% under standard resting adult assumptions from the source-reported 1.5 L/min pure-H₂ flow. The present findings showed that hydrogen/oxygen inhalation shortened the virus shedding duration, decreased the inflammatory factor levels, as well as resolved the pulmonary lesions compared to oxygen inhalation alone, thereby reducing the occurrence of severe cases in the early stage. In terms of inflammatory indicators, The IL-6 levels in hydrogen/oxygen group decreased by 22.8% compared with the baseline, while which of the oxygen group slightly increased on the 3rd day.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 64 patients with COVID-19. The reported sample size was 64. The study used a randomized human clinical trial. The source-reported hydrogen concentration was 50% source-reported H₂ gas concentration. H2HUBB estimated inhaled H₂ concentration: approximately 5.0–6.7% under standard resting adult assumptions from the source-reported 1.5 L/min pure-H₂ flow. This is a calculated estimate, not a directly measured concentration, and actual inhaled H₂ varies with breathing pattern, ventilation, cannula capture, and gas losses.
Limitations and Safety
Reported limitations: The relatively small sample might bring bios of the results, e.g., the anti-inflammatory trend was seen after hydrogen/oxygen inhalation, but without any statistical significance.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.