The interactions of nitric oxide with intracellular redox status and the influence of molecular hydrogen.
John T Hancock, Francisco J Corpas, Zsuzsanna Kolbert, Neidiquele M Silveira, Kapuganti Jagadis Gupta · Nitric oxide : biology and chemistry · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. One characteristic of cells which is crucial to the control of cellular activity is the intracellular redox state, and this is maintained by compounds such as glutathione (GSH), but also impinged upon by ROS, reactive sulfur compounds such as hydrogen sulfide (H2S), and potentially by hydrogen gas (H₂). The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. One characteristic of cells which is crucial to the control of cellular activity is the intracellular redox state, and this is maintained by compounds such as glutathione (GSH), but also impinged upon by ROS, reactive sulfur compounds such as hydrogen sulfide (H2S), and potentially by hydrogen gas (H₂).
What the Researchers Studied
The authors reviewed the interactions of nitric oxide with intracellular redox status and the influence of molecular hydrogen.
What Effects Did Molecular Hydrogen Have?
One characteristic of cells which is crucial to the control of cellular activity is the intracellular redox state, and this is maintained by compounds such as glutathione (GSH), but also impinged upon by ROS, reactive sulfur compounds such as hydrogen sulfide (H2S), and potentially by hydrogen gas (H₂).
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.