Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.
Qiuhong Jiao, Yanfang Yang, Xiufeng Xu, Jie Hao, Jiaru Guo, Guangshuang Wu, Shulan Pang, Weiwei Yang, Yudan Zhao, Lijuan Wang, Hongjie Wang, Peikang Dong, Yingshuai Wang, Tao Wang · Free radical biology & medicine · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Molecular hydrogen (H₂), a biologically safe therapeutic agent with exceptional antioxidative, anti-inflammatory, anti-apoptotic properties and autophagic flux-modulating activities, has demonstrated organoprotective efficacy in cardiovascular and cerebrovascular disorders. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Molecular hydrogen (H₂), a biologically safe therapeutic agent with exceptional antioxidative, anti-inflammatory, anti-apoptotic properties and autophagic flux-modulating activities, has demonstrated organoprotective efficacy in cardiovascular and cerebrovascular disorders.
What Effects Did Molecular Hydrogen Have?
Molecular hydrogen (H₂), a biologically safe therapeutic agent with exceptional antioxidative, anti-inflammatory, anti-apoptotic properties and autophagic flux-modulating activities, has demonstrated organoprotective efficacy in cardiovascular and cerebrovascular disorders. Clinical translation is hindered by hydrogen's high explosivity and low bioavailability, necessitating the development of safer and more efficient delivery strategies. This study developed novel hydrogen-releasing magnesium diboride nanosheets (MBNs), and employs an integrated transcriptomic-proteomic approach to investigate the cardioprotective effects of MBNs against PAH-induced RHF and elucidate its underlying molecular targets and mechanisms of action.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.