Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
Wen-Wen Cai, Ming-Hua Zhang, Yong-Sheng Yu, Jin-Hua Cai · Molecular and cellular biochemistry · 2013
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Independent study record
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H2HUBB TAKEAWAY
Recently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
How Molecular Hydrogen Was Addressed
Recently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. In this study, the researchers investigated the effect of treatment with hydrogen molecule (H(2)) on TNFα-induced cell injury in osteoblast.
What the Publication Reported
Incubation with TNFα-enhanced intracellular reactive oxygen species (ROS) formation and malondialdehyde production increased NADPH oxidase activity, impaired mitochondrial function marked by increased mitochondrial ROS formation and decreased mitochondrial membrane potential and ATP synthesis, and suppressed activities of antioxidant enzymes including SOD and catalase, which were restored by co-incubation with H(2).
H₂ Mechanisms / Biological Findings
Recently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases.
Authors’ Conclusion
The authors concluded that , treatment with H(2) alleviates TNFα-induced cell injury in osteoblast through abating oxidative stress, preserving mitochondrial function, suppressing inflammation, and enhancing NO bioavailability.