Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation.
In rats, hRS decreased P-selectin expression, release of thromboxane B2, ROS, and fibrinogen binding, but enhanced NO levels in H₂O₂-exposed platelets. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats.
The researchers observed that hydrogen treatment partially reversed the increase in lung tissue density and reduced pulmonary inflammation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreNanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
The researchers observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH2 treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats.
The researchers found that H₂-O₂ mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac apoptosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
In an animal model, regarding the neurological score, the piglets in the TH-H₂ group consistently had the highest score from day 2 to 5 and showed a significantly higher neurological score from day 3 compared with the NT group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEngineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects.
In an animal model, the released hydrogen gas can effectively regulate redox homeostasis and mitigate excessive inflammation, and the silicic acid can promote the proliferation of reparative cells and enhance their osteogenic differentiation, indicative of osteoinductivity. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreStimulating fermentation by the prolonged acceleration of gut transit protects against decompression sickness.
In rats, pEG led to a significant increase in exhaled H₂ (35 ppm [10-73] compared with control 7 ppm [2-15]; p = 0.001). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.
In guinea pigs, the ABR thresholds at 2 and 4 kHz were significantly better on post-noise days 1, 3, and 14 in hydrogen-treated animals when compared to the normal water-treated controls. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs
In guinea pigs, the ABR thresholds measured immediately after the simultaneous exposure to noise and carbon monoxide significantly increased at all frequencies in group 1 while in group 2, the ABR thresholds measured immediately after the inhalation of hydrogen significantly reduced at 4, 8, and 16 kHz (P values 0.05) ( Figure 1 ). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreElectrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats.
In rats, these results suggest the possibility that this drinking water shows an effect in reduction of oxidative stress in the body. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MorePrevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil.
In an animal model, when the animals were treated with hydrogen-rich water, cochlear damage was significantly reduced: the increase in ABR threshold was 11.7±2.6dB at 8kHz and the IHC loss was 7.5%±2.1% at the basal turn on day 7. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreRenoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent.
In rats, these findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs.
In an animal model, H₂ treatment essentially prevented the increases in COX-2-immunopositive neurons. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy.
In an animal model, H₂ was neuroprotective shown both by the enhanced recovery of EEG and by the significant preservation of neurons in the cerebral cortex, hippocampus, basal ganglia, and the thalamus. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen helps to ameliorate Staphylococcus aureus-induced mastitis in mice.
In mice, this study indicates that hydrogen helps to ameliorate S. aureus-induced mastitis in mice through attenuating TLR2 and Nod2 mediated NF-κB and MAPK activation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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