MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline.
This animal study examined MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Collectively, miR-199a-3p may serve a key role in the anti-apoptotic mechanism of HRS that contributes to its protection of the intestine against I/R injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice.
This animal study examined Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice. The abstract describes Mouse model; reported duration 4 weeks. The abstract reports: Results of 16S rRNA gene sequencing analyses showed that the relative abundances of 20 taxa differed significantly in AEW-administered mice. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.
This uncontrolled human study examined Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Molecular hydrogen can promote PKM2 lactylation to restrain NLRP3 inflammasome-mediated pyroptosis and inflammation, thus ameliorating UC progression. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression.
This animal study examined Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: The histological study demonstrated milder inflammation in the DSS + HRW group, which was similar to normal inflammatory levels, and the macroscopic and microcosmic…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
This animal study examined Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhaled hydrogen ameliorates endotoxin-induced bowel dysfunction.
This uncontrolled human study examined Inhaled hydrogen ameliorates endotoxin-induced bowel dysfunction. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: This study showed the protective effects of hydrogen inhalation on LPS-induced septic ileus through inhibition of inflammation in the muscularis propria. These inhibitory effects…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total‐layer necrosis: An experimental swine model study
This animal study examined Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total‐layer necrosis: An experimental swine model study. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: Although critically ill conditions can trigger NOMI, the model used in this study did not involve transmural necrosis. Under such conditions, hydrogen inhalation therapy…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice.
This animal study examined A preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice. The abstract describes Mouse model; sample size 10. The abstract reports: Our findings suggest that treatment with molecular hydrogen may affect microbiota profiling and suppress intestinal injury in HFD-loaded SAMP8. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial.
: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis. : In this randomised, double-blind, placebo-controlled trial, 10 active patients with ulcerative colitis (aged ≥20 years; Lichtiger's clinical activity index, 3-10; and Mayo endoscopic subscores ≥1) participated, and they were assigned to either a hydrogen or air inhalation group (hydrogen and…
Read MoreHydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 and NF-κB Signaling Pathways.
This animal study examined Hydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 and NF-κB Signaling Pathways. The abstract describes Rat model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: The obtained results show that hydrogen-rich water significantly increased the levels of superoxide dismutase and structural proteins; activated the Nrf-2 signaling pathway; downregulated the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice.
This animal study examined Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Effects of Hydrogen Gas on Experimental Acute Pancreatitis.
This uncontrolled human study examined Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis. The abstract describes Human participants. The abstract reports: The results revealed significant reductions in inflammation and oxidative stress both in vitro and in vivo. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats.
This animal study examined Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 5 days. The abstract reports: Sirt1 mediates light-induced damage mitigation by HRS through inhibition of apoptosis and oxidant-stress. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats.
This animal study examined The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Oxidative stress has been identified as one of the contributing mechanisms of spaceflight-associated neuro-ocular syndrome (SANS), and hydrogen (H) has demonstrated significant antioxidant and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.
This animal study examined Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results showed that administration of HPC significantly inhibited the apoptosis of RGCs and protected the visual function. This is an automated editorial draft based on the abstract and requires source review before publication.
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