Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial.

The publication “Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial.” is organized in H2HUBB under the research focus hydrogen gastrointestinal study 2025. The publication is cited as Maruyama T, Ishikawa D, Kurokawa R, Masuoka H, Nomura K, Haraikawa M, Orikasa M, Odakura R, Koma M, Omori M, Ishino H, Ito K, Shibuya T, Suda W, Nagahara A, Biomedicines, 2025. This randomized controlled trial examined Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 8 weeks. The abstract reports: The hydrogen group showed higher α-diversity ( = 0.19), and the variation in β-diversity was markedly different, compared to the placebo group, in intestinal…. This is an automated editorial draft based on the abstract and requires source review before publication.

Hydrogen gastrointestinal study 2025 overview

In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis. : In… Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.

Study design and hydrogen intervention

Publication type: Randomized controlled trial. Evidence type: Human clinical evidence. Research model or population: Human participants. Randomized: Yes. Blinding: Double-blind. Control status: Placebo-controlled.

Delivery method: Hydrogen inhalation. Treatment duration: 8 weeks.

Reported findings and scientific interpretation

For this hydrogen gastrointestinal study 2025, the study record reports the following: The abstract reports: The hydrogen group showed higher α-diversity ( = 0.19), and the variation in β-diversity was markedly different, compared to the placebo group, in intestinal…

These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.

How this research record was prepared

H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.

Limitations, safety, and original source

Limitations: Further studies are needed, and hydrogen inhalation may possibly lead to a logical solution combined with microbiome therapy, such as faecal microbiota transplantation, with…

Safety: In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis. : In…

This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.