Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus.
In rats after transient global cerebral ischemia, inhaling 2.1% hydrogen-supplemented air prevented ischemia-associated changes in COX-2, nitric-oxide synthase, and connexin protein expression in the hippocampus and cortex. These results are preclinical and suggest molecular hydrogen's therapeutic potential for reducing secondary neuronal injury. Further human research is needed to establish clinical effectiveness.
Read MoreBeneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.
In rabbits with spinal-cord ischemia-reperfusion injury, inhaling 2% or 4% H₂ improved hind-limb motor function and motor-neuron preservation and reduced oxidative products, inflammatory cytokines, and neuronal apoptosis. These results are preclinical and suggest molecular hydrogen's therapeutic potential for spinal-cord reperfusion injury. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen concentration in rat.
In rats continuously inhaling 3% H₂, tissue concentrations rose at different rates, taking longest to saturate in muscle and reaching the highest maximum in liver and the lowest in kidney. This preclinical pharmacokinetic study describes organ distribution rather than therapeutic efficacy, and human tissue distribution requires separate study.
Read MoreThe effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
In mice undergoing transient bilateral carotid-artery occlusion, 1.3% H₂ had no significant effect on vital signs or cortical blood flow, but it reduced 8-OHdG expression, hippocampal neuronal injury, and brain water content after ischemia. These mixed preclinical results suggest molecular hydrogen's therapeutic potential for limiting ischemic tissue injury. Further human research is needed to establish clinical effectiveness.
Read MoreMolecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.
In sedentary rats running to exhaustion, inhalation of an H₂-containing gas mixture increased exercise-associated SOD activity and blunted lipid peroxidation, inflammatory cytokine surges, NF-κB phosphorylation, and cleaved caspase-3 expression. These results are preclinical and suggest molecular hydrogen's therapeutic potential for limiting acute exhaustive-exercise muscle damage. Further human research is needed to establish clinical effectiveness.
Read MoreMolecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
In rats with experimentally induced chronic heart failure, inhaling 2% H₂ once or for 40 minutes daily over 5 days reduced circulating endothelial-cell counts and was accompanied by recovery of myocardial structure and lower heart weight. These results are preclinical and suggest molecular hydrogen's therapeutic potential for endothelial and cardiac remodeling. Further human research is needed to establish clinical effectiveness.
Read MoreInhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.
In mice exposed to intermittent hypoxia, 1.3% H₂ inhalation suppressed dyslipidemia, myocardial superoxide production, inflammatory gene expression, cardiomyocyte hypertrophy, mitochondrial degeneration, and fibrosis. These results are preclinical and suggest molecular hydrogen's therapeutic potential for cardiac remodeling associated with sleep-apnea-like intermittent hypoxia. Further human research is needed to establish clinical effectiveness.
Read MoreMolecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation.
In male Wistar rats with LPS-induced systemic inflammation, 2% H₂ inhalation reduced pro-inflammatory cytokines, increased IL-10, prevented fever, and during severe inflammation prevented hypotension while potentiating hypothermia. These results are preclinical and suggest molecular hydrogen's therapeutic potential for inflammatory and thermoregulatory responses. Further human research is needed to establish clinical effectiveness.
Read MoreNeuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
In 5xFAD mice, inhaling 2% H₂ for 1 hour per day over 4 weeks reduced hippocampal oxidative stress and Aβ42 burden, increased catalase activity and ATP, and shifted inflammatory and cell-survival signaling in a neuroprotective direction. These results are preclinical and suggest molecular hydrogen's therapeutic potential for mechanisms relevant to Alzheimer’s disease. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation cardiac arrest study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Hydrogen Inhalation During Normoxic […]
Read MoreGlobal and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation copd study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Global and regional mortality from […]
Read MoreHydrogen Gas Inhalation Inhibits Progression to the “Irreversible” Stage of Shock After Severe Hemorrhage in Rats
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation research study 20487: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Hydrogen gas inhalation inhibits […]
Read MoreFeasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome: First-in-Human Pilot Study
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation cardiac arrest study 21422: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Abstract 14562: First-in-human […]
Read MoreInhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation research study 21224: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Inhaled Hydrogen Gas Therapy […]
Read MoreFatigue Disappearance in Hemodialysis Patients by Dual Approach With Hydrogen Gas Inhalation and Hydrogen-Enriched Dialysate: Two Case Reports
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation dialysis study 2025: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Fatigue disappearance in hemodialysis […]
Read MoreBlog Categories
Recent Posts
October 21, 2020
November 16, 2020
October 02, 2017