Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
Pei Wang, Liyan Jia, Bihua Chen, Lei Zhang, Jiankang Liu, Jiangang Long, Yongqin Li · Shock (Augusta, Ga.) · 2016
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Independent study record
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H2HUBB TAKEAWAY
Serum cardiac troponin T and S100B measured during earlier post-resuscitation period were markedly reduced in both H₂ inhalation and hypothermic groups. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
In the present study, the researchers investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac arrest.
How Molecular Hydrogen Was Used
Animals were randomly assigned to three experimental groups immediately after successful resuscitation: ventilation with 2% hydrogen/98% oxygen under normothermia (H₂ inhalation), ventilation with 2% nitrogen/98% oxygen under normothermia (Control), and ventilation with 2% nitrogen/98% oxygen under hypothermia (TH).
What the Researchers Found
Ninety-six hours survival rate was significantly higher in the H₂ inhalation group (75.0%), either compared with TH (45.8%) or compared with Control (33.3%). Serum cardiac troponin T and S100B measured during earlier post-resuscitation period were markedly reduced in both H₂ inhalation and hypothermic groups. However, significantly better left ventricular ejection fraction, cardiac work, and neurological deficit score were observed in the H₂ inhalation group.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that small amounts of inhaled hydrogen were superior to mild hypothermia in improving cardiac function and neurological outcome in this asphyxial rat model of cardiac arrest.