A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.

This narrative review examined A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine. The abstract describes Published literature review; hydrogen delivered as hydrogen water and hydrogen-rich saline and hydrogen bath and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.

This in vitro or cellular study examined Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Intraperitoneal administration of H2-rich saline resulted in large increases in H2 concentration in the IVC ranging from 0.00183 mg/L (0.114%) to 0.00725 mg/L (0.453%). This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma.

This animal study examined Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: These findings suggest that hydrogen-rich saline reduces airway inflammation and remodeling in OVA-exposed mice by inhibiting NF-κB. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs.

This animal study examined Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs. The abstract describes Animal model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives.

This narrative review examined A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives. The abstract describes Published literature review; hydrogen delivered as hydrogen water and hydrogen-rich saline. The abstract reports: H has been found to have selective antioxidant properties against the most dangerous oxidants (hydroxyl radicals and peroxynitrite). This is an automated editorial draft based on the abstract and requires source review before publication.

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Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis.

This meta-analysis examined Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis. The abstract describes Published literature review; hydrogen delivered as hydrogen water and hydrogen-rich saline and hydrogen bath. The abstract reports: Subgroup analyses revealed that H supplementation showed greater improvement (SMD = 0.52, 95%CI 0.16 to 0.87,  = 0.02) in the antioxidant potential capacity of intermittent exercises than…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.

This animal study examined Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 12 weeks. The abstract reports: ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.

This animal study examined Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. The abstract describes Rat model; sample size 30; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. This is an automated editorial draft based on the abstract and requires source review before publication.

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Evaluation of the effect of enriched hydrogen saline solution on distant organ (lung) damage in skeletal muscle ischemia reperfusion in rats.

This animal study examined Evaluation of the effect of enriched hydrogen saline solution on distant organ (lung) damage in skeletal muscle ischemia reperfusion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS at a dose of 20 mg/kg, administered intraperitoneally 30 min before ischemia in rats, reduced lipid peroxidation and oxidative stress, while also reducing IR damage…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs.

This uncontrolled human study examined Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. This is an automated editorial draft based on the abstract and requires source review before publication.

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Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats.

This animal study examined Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water and hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The results showed that hydrogen water ameliorated these alterations, demonstrating that hydrogen water alleviated paraquat-induced acute lung injury possibly by inhibition of oxidative damage. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury.

This animal study examined Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS or HBO2 single treatment could decrease inflammatory cytokines release in lung tissue, reduce the accumulation of oxidative products and alleviate apoptosis of pulmonary…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effects of molecular hydrogen on lung injury from lung transplantation

This narrative review examined Protective effects of molecular hydrogen on lung injury from lung transplantation. The abstract describes Published literature review; hydrogen delivered as hydrogen water and hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The reviewed studies showed that H improved the outcomes of lung transplantation by decreasing oxidative stress and inflammation at the donor and recipient phases. This is an automated editorial draft based on the abstract and requires source review before publication.

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Saturated hydrogen saline protects the lung against oxygen toxicity.

This animal study examined Saturated hydrogen saline protects the lung against oxygen toxicity. The abstract describes Mouse model; hydrogen delivered as hydrogen water and hydrogen-rich saline. The abstract reports: The light microscope findings showed that saturated hydrogen saline reduced the impairment when compared with the saline group: Saturated hydrogen saline decreased lung edema,…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival.

This animal study examined Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation and hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The study highlights that continuous inhalation of hydrogen gas at a 2 % concentration for 24 h can be a potent intervention in the geriatric population…. This is an automated editorial draft based on the abstract and requires source review before publication.

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