Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats
This animal study examined Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats. The abstract describes Rat model; sample size 30; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.
This uncontrolled human study examined Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. The abstract reports: Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress.
This animal study examined Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. The abstract describes Rat model; sample size 30; reported duration 3 hours. The abstract reports: Inhalation of hydrogen gas could attenuate cognitive impairment in the ischemic rats. This protection is associated with decreased neuronal death in CA1 region and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.
This uncontrolled human study examined Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats. The abstract describes Human participants. The abstract reports: H therapy improved mortality in highly lethal CA rats rescued by ECPR and helped recover brain electrical activity. The underlying mechanism might be linked…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
This uncontrolled human study examined Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Hydrogen-rich saline can exert a protective effect against TBI via reducing oxidative stress. Molecular hydrogen may be a more effective therapeutic strategy for TBI…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of hydrogen gas on the survival rate of mice following global cerebral ischemia.
This animal study examined Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. The abstract describes Mouse model; sample size 12. The abstract reports: Global cerebral ischemia and reperfusion (I/R) often result in high mortality. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
This animal study examined Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. The abstract describes Rat model; reported duration 2 hrs. The abstract reports: Hydrogen gas could exert its neuroprotective effect against early brain injury after subarachnoid hemorrhage by its antioxidative activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro
Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential secondary messengers that activate the NLRP3 inflammasome.
Read MoreHydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury.
This animal study examined Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen, which is a slight and specific cytotoxic oxygen radical scavenger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves a key role in inflammatory response, which may lead to endothelial cell injury and blood-brain barrier (BBB) disruption. Hydrogen (H) is considered a neuroprotective antioxidant.
Read MoreHydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
This animal study examined Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results of this study demonstrate that hydrogen-rich saline improves neurological outcomes in mice and reduces neuronal death by protecting against neural autophagy and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLongitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats.
This animal study examined Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats. The abstract describes Rat model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTranscriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model.
This in vitro or cellular study examined Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model. The abstract describes Artificial skin model; hydrogen delivered as hydrogen inhalation. The abstract reports: This study demonstrated that photoaging-related transcriptomic changes were detectable in artificial skin under a relatively low UVA dose (7 J/cm/day; total 21 J/cm) with minimal histological…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBeneficial effects of hydrogen-rich saline on early burn-wound progression in rats.
This animal study examined Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen can attenuate early wound progression following deep burn injury. The beneficial effect of hydrogen was mediated by attenuating oxidative stress, which inhibited apoptosis…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells.
This in vitro or cellular study examined Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. The abstract describes HaCaT keratinocyte model. The abstract reports: All of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8‑iso‑prostaglandin F2α and malondialdehyde, and promoted the UVB exposure‑induced expression…. This is an automated editorial draft based on the abstract and requires source review before publication.
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