Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism.

This meta-analysis examined Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism. The abstract describes Published literature review; sample size 1088; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Dihydrogen is a medical gas with extensively documented antioxidant, anti-inflammatory, and signaling properties, validated in over 1000 studies across more than 100 disease models,1…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen is neuroprotective against surgically induced brain injury.

This uncontrolled human study examined Hydrogen is neuroprotective against surgically induced brain injury. The abstract describes Human participants. The abstract reports: SBI resulted in localized brain edema (p = < 0.001). This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats.

This animal study examined Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation and hydrogen-rich saline. The abstract reports: Further studies showed that hydrogen significantly upregulated the expression of nuclear factor erythroid-2-related factor 2 and downstream proteins such as catalase and hemeoxygenase-1 in…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes.

This animal study examined Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that HRW significantly attenuated HI-induced oxidative stress in the brain pericytes of neonatal rats, partly through the Nrf2-HO-1 pathway, further improving…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans.

This uncontrolled human study examined Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. The abstract describes Human participants. The abstract reports: We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

This uncontrolled human study examined Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy. The abstract describes Human participants. The abstract reports: This case suggests that molecular hydrogen therapy may be a helpful adjunct treatment for SDH with midline shift. Conventional therapies, including craniectomy, hyperbaric oxygen,…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury.

This animal study examined Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers.

This randomized controlled trial examined Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 15 min. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

This narrative review examined Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders. The abstract describes Published literature review. The abstract reports: Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

This animal study examined Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: These results suggested that H2 holds promise for the prevention of inflammation related to perinatal brain injury. This is an automated editorial draft based on the abstract and requires source review before publication.

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Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.

This animal study examined Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Our results suggest that LPS-induced apoptosis, oxidative damage and inflammation in the fetal brain were ameliorated by maternal H2 administration. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.

This uncontrolled human study examined Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. The abstract describes Human participants. The abstract reports: HG was found to induce severe oxidative stress and promote the caspase‑dependent and caspase‑independent apoptosis of SCs. This is an automated editorial draft based on the abstract and requires source review before publication.

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Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.

This animal study examined Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: H is identified as a potent agent against NEMP exposure-induced brain damage and has the potential to be a promising electromagnetic radiation protectant. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hyperbaric hydrogen therapy improves secondary brain injury after head trauma.

This animal study examined Hyperbaric hydrogen therapy improves secondary brain injury after head trauma. The abstract describes Mouse model; sample size 40; reported duration 90 minutes. The abstract reports: Hyperbaric hydrogen therapy may be effective for posttraumatic secondary brain injury. This is an automated editorial draft based on the abstract and requires source review before publication.

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Phosphorylation-mediated PI3K-Art signalling pathway as a therapeutic mechanism in the hydrogen-induced alleviation of brain injury in septic mice.

This animal study examined Phosphorylation-mediated PI3K-Art signalling pathway as a therapeutic mechanism in the hydrogen-induced alleviation of brain injury in septic mice. The abstract describes Mouse model. The abstract reports: In proteomics and phosphoproteomics analysis, 268 differentially phosphorylated proteins (DPPs) showed a change in the phosphorylated form in the CLP + H group (p . This is an automated editorial draft based on the abstract and requires source review before publication.

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