Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism.
Nikola Todorović, Jovan Kuzmanović, Dejan Javorac, Sergej M. Ostojic · Medical Gas Research · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism.” is organized in H2HUBB under the research focus hydrogen inhalation diabetes metabolic study 2025. The publication is cited as Nikola Todorović, Jovan Kuzmanović, Dejan Javorac, Sergej M. Ostojic, Medical Gas Research, 2025. This meta-analysis examined Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism. The abstract describes Published literature review; sample size 1088; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Dihydrogen is a medical gas with extensively documented antioxidant, anti-inflammatory, and signaling properties, validated in over 1000 studies across more than 100 disease models,1…. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation diabetes metabolic study 2025 overview
While traditional pharmaceutical interventions have shown benefits, they often come with limitations, including side effects and/or high costs, highlighting the importance of investigating alternative… A review depends on the quality, comparability, and risk of bias of the studies it includes; it does not create stronger evidence than the underlying research.
Study design and hydrogen intervention
Publication type: Meta-analysis. Evidence type: Review or synthesis. Research model or population: Published literature review. Sample size: 1088. Randomized: Yes. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen inhalation.
Reported findings and scientific interpretation
For this hydrogen inhalation diabetes metabolic study 2025, the study record reports the following: The abstract reports: Dihydrogen is a medical gas with extensively documented antioxidant, anti-inflammatory, and signaling properties, validated in over 1000 studies across more than 100 disease models,1…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Review conclusions depend on the quality, consistency, and heterogeneity of the included studies.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.