Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway
This animal study examined Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. The abstract describes Mouse model; sample size 6. The abstract reports: Our findings indicate that HCH may protect the liver against I/R injury through the A dependent PI3K-Akt pathway. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePossible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation
This observational study examined Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. The abstract describes Human participants. The abstract reports: The data indicates E-HD could have substantial clinical benefits beyond conventional HD therapy, and support the rationale to conduct clinical trials of H2 application…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.
This in vitro or cellular study examined Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. The abstract describes Lymphocyte cell model. The abstract reports: These results indicate that H(2) released from intestinal bacteria can suppress inflammation induced in liver by ConA. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreIntake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.
This animal study examined Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that intake of HRW had no significant effect on the activities of various cytochrome P450 (CYP) enzymes (CYP1A1, 1A2, 2B, 2C,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreNanocapsule-mediated sustained H release in the gut ameliorates metabolic dysfunction-associated fatty liver disease.
This uncontrolled human study examined Nanocapsule-mediated sustained H release in the gut ameliorates metabolic dysfunction-associated fatty liver disease. The abstract describes Human participants. The abstract reports: Moreover, hepatic transcriptome showed a reprogramed liver metabolism profile with reduced lipid synthesis and increased fatty acid metabolism. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
This animal study examined Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. The abstract describes Rat model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions.
This animal study examined Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions. The abstract describes Rat model. The abstract reports: The mechanism of this phenomenon suggests that H2 may have effectively attenuated AOC‑induced inflammatory and oxidative damage, and decreased matrix metalloproteinase activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
This animal study examined Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation. The abstract describes Rat model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: Storage of liver grafts in hydrogen-rich UW solution resulted in superior functional and morphologic protection against IRI via the up-regulation of HO-1 expression. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection.
This animal study examined Inhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation; reported duration 120 minutes. The abstract reports: In this experimental study, we showed that inhaled hydrogen during major liver resection unquestionably reduced the level of oxidative stress associated with ischemia-reperfusion damage.…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
This animal study examined Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. The abstract describes Rat model. The abstract reports: We found that H2 ameliorated H/R-induced cholangiocytes apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
This uncontrolled human study examined Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: HRW significantly attenuates oxidative stress in CHB patients, but further study with long-term treatment is required to confirm the effect of HRW on liver…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAnti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
This animal study examined Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. The abstract describes Mouse model. The abstract reports: It has been suggested therefore to use gaseous hydrogen in a new anti-inflammatory strategy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease.
This animal study examined A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: In the present study, we found that HRCC treatment improved methionine-and-choline-deficient diet (MCD)-induced hepatic steatosis, increased aspartate aminotransferase and alanine aminotransferase levels, and elevated…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLong-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways.
This animal study examined Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways. The abstract describes Rat model. The abstract reports: Rats exposed 2 h daily to H either by drinking HRW (H dissolved in HO) or by breathing 4% H gas showed reduced lipogenesis and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
This animal study examined A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.
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