Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
This animal study examined Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: This study extended our original analysis of the ability of hydrogen to stimulate NLRP3 inflammasome/GSDMD activation in pyroptosis and revealed possible mechanism (s) for…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSuppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis.
This in vitro or cellular study examined Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis. The abstract describes A549 cell model. The abstract reports: Our previous study found that hydrogen gas (H) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.
This uncontrolled human study examined Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. The abstract describes Human participants; sample size 55; hydrogen delivered as hydrogen inhalation. The abstract reports: Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension
This animal study examined Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. The abstract describes Rat model. The abstract reports: Our findings suggest that chronic H gas inhalation may help prevent LV hypertrophy in hypertensive DS rats. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtection of oral hydrogen water as an antioxidant on pulmonary hypertension
This animal study examined Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT group were significant higher than…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
Molecular hydrogen (H) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H on lung inflammation and blood pressure. In this study, we further focused the biological effects of H on mast cells (MCs) and the parameters of the fibrotic phenotype of the local tissue microenvironment.
Read MoreHydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation
This animal study examined Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation. The abstract describes Rat model; reported duration 5 weeks. The abstract reports: We found that the systolic and diastolic blood pressure (BP) increased significantly in rats exposed to intermittent hypoxia, both of which were markedly attenuated…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats.
This animal study examined Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
This animal study examined Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats, which may be associated with its antioxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreConsumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
This uncontrolled human study examined Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
This animal study examined Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. The abstract describes Rat model. The abstract reports: Molecular hydrogen ameliorates MCT-induced PAH in rats by suppressing macrophage accumulation, reducing oxidative stress and modulating the STAT3/NFAT axis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAdjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes
Pulmonary arterial hypertension (PAH) is a significant and challenging complication for patients with systemic lupus erythematosus (SLE). It is thought to arise from immune dysregulation and vascular remodeling, ultimately leading to progressive right heart failure. Molecular hydrogen therapy, a selective antioxidant and anti-inflammatory agent, may modulate the immune responses seen in autoimmune diseases.
Read MoreHydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
This animal study examined Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: The results showed that, although hydrogen inhalation had no effect on the main markers of pulmonary hypertension induced by monocrotaline injection, there was a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis.
Molecular hydrogen (H) demonstrates selective antioxidant and anti-inflammatory properties with therapeutic potential across musculoskeletal conditions including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage, chronic pain syndromes, tendinopathies, and muscle atrophy. This review critically evaluates preclinical and clinical evidence for H therapy and identifies research gaps. A comprehensive search of PubMed, EMBASE, and Cochrane Library (up to April 2025) yielded 45 eligible studies: 25 preclinical and 20 clinical trials.
Read MoreDaily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
This animal study examined Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. The abstract describes Rat model. The abstract reports: A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H) improves blood pressure control in end-stage kidney disease. This is an automated editorial draft based on the abstract and requires source review before publication.
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