Molecular hydrogen generated by elemental magnesium supplementation alters rumen fermentation and microbiota in goats.
The researchers tested the hypotheses that supplementation of a diet with elemental Mg increases ruminal dissolved H₂ (dH2) in rumen fluid, which in turn alters rumen fermentation and microbial community in goats. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota.
In mice, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreMicrobial imbalance in inflammatory bowel disease patients at different taxonomic levels.
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Molecular hydrogen inflammatory bowel study 2024: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Microbial imbalance in […]
Read MoreEffects of Hydrogen-Rich Water on Juvenile Largemouth Bass (Micropterus salmoides) Under Acute Low-Temperature Stress.
Showed that after 30 days of HRW rearing, the final body weight (FBW), specific growth rate (SGR), and condition factor (CF) of the H1 group were significantly increased, while the H3 group only increased CF. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreInadequate Production of H2 by Gut Microbiota and Parkinson Disease.
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals.
In 118 participants with mild-to-moderate dry eye symptoms, a significant decline in fTBUT was observed in the placebo group (p = 0.04), but not the H₂-producing group (p = 0.26). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
Read MoreMolecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application.
This narrative review examined the available molecular-hydrogen literature. Due to its high bioavailability, H₂ is considered a therapeutic gas for the treatment of various diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMetabolism of hydrogen gases and bile acids in the gut microbiome.
This narrative review examined the available molecular-hydrogen literature. Hence, at low H₂ levels, E. lenta is proposed to use NADH from bile acid hydroxyl group oxidations to reduce CO₂ to acetate. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMicrobial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.
In mice, exogenous H₂ reprograms colonocyte metabolism by regulating the H₂-gut microbiota-SCFAs axis and strengthens the intestinal barrier by modulating specific mucosa-associated mucolytic bacteria, wherein improved microbial hydrogen economy alleviates colitis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of Long-Term Hydrogen Intervention on Plasma Metabolites and Gut Microbiome of Rats in Health Status
In an animal model, HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
In mice, molecular hydrogen treatment improved gut microbiota dysbiosis and partially amended metabolic disorder after SAE. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreDrinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota.
The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota.
In the present study, the researchers found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MorePositive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease.
In rats, increased gut permeability, measured by FITC-dextran assay, was detected in PERM group compared to control and PERM+ERW groups. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.
In mice, these findings suggest that molecular hydrogen attenuates HFHSD-induced metabolic disturbances primarily through suppression of adipose inflammation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreBlog Categories
Recent Posts
October 21, 2020
November 16, 2020
October 02, 2017