Advances in hydrogen delivery strategies for therapeutic applications.
Lam-Duc-Huy Nguyen, Sheng-Yao Peng, Cam-Hoa Mac, Nhien Nguyen, Shih-Kai Lo, Po-Hsi Lin, Ninh-Son Pham, Hsiao-Huang Chang, Yu-Jung Lin, Hsing-Wen Sung · Advanced drug delivery reviews · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. To overcome these barriers, a variety of advanced H₂-delivering systems have been developed, including H₂-containing carriers and in situ H₂-generating materials based on water-, acid-, and electrochemical reactions. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Main Findings Across the Literature
To overcome these barriers, a variety of advanced H₂-delivering systems have been developed, including H₂-containing carriers and in situ H₂-generating materials based on water-, acid-, and electrochemical reactions.
Areas of Agreement or Uncertainty
Despite encouraging findings from preclinical and clinical studies, conventional delivery routes-such as inhalation, oral intake of H₂-rich water, or injection of H₂-rich saline-face critical limitations in stability, bioavailability, and targeted delivery, impeding clinical translation.
Limitations Reported by the Authors
Despite encouraging findings from preclinical and clinical studies, conventional delivery routes-such as inhalation, oral intake of H₂-rich water, or injection of H₂-rich saline-face critical limitations in stability, bioavailability, and targeted delivery, impeding clinical translation.