Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.
Branislav Kura, Maria Szantova, Tyler W LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, Barbora Kalocayova, Matus Sykora, Ludmila Okruhlicova, Narcisa Tribulova, Anna Gvozdjakova, Zuzana Sumbalova, Jarmila Kucharska, Xenia Faktorova, Martina Jakabovicova, Zuzana Durkovicová, Jan Macutek, Michaela Koscová, Jan Slezak · Antioxidants (Basel, Switzerland) · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 30 participants with NAFLD, HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels. These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 30 participants with NAFLD. HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels.
What the Researchers Studied
The researchers studied 30 participants with NAFLD. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 4 mg/L H₂; Source-reported hydrogen exposure: 330 mL hydrogen-rich water per serving, 3 servings/day; approximately 1.32 mg H₂ per reported serving; H2HUBB calculated daily H₂ dose: approximately 3.96 mg H₂/day, calculated from the source-reported dissolved H₂ concentration and total hydrogen-water volume consumed per day. HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels. The authors concluded that the favorable trends in this study in conjunction with previous animal and clinical findings suggest that HRW may serve as an important adjuvant therapy for promoting and maintaining optimal health and wellness. Unlike with exercise or molecular hydrogen, the oxidative stress in the diseased states remain chronically elevated, which results in antioxidant depletion and cellular injury. to its known antioxidant effects, molecular hydrogen has also been shown to exert selective anti-inflammatory effects [ 4 ].
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 30 participants with NAFLD. The reported sample size was 30. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 4 mg/L H₂. The source-reported hydrogen exposure was 330 mL hydrogen-rich water per serving, 3 servings/day; approximately 1.32 mg H₂ per reported serving. This is a deterministic dose translation, not a separately measured value.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.