Case report
SLAVE · Brazilian Journal of Veterinary Pathology · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In with acute cerebral infarction, 4°C HRSS and 24°C HRSS administration alleviated plasma liver enzymes The activities of AST and ALT were significantly higher in rats exposed to hepatic I/R injury compared with Golshahi, et al.; Protective effect of intraportal infusion of hypothermic hydrogen-rich water solution on hepatic warm ischemia/reperfusion injury in rat model. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in with acute cerebral infarction. 4°C HRSS and 24°C HRSS administration alleviated plasma liver enzymes The activities of AST and ALT were significantly higher in rats exposed to hepatic I/R injury compared with Golshahi, et al.; Protective effect of intraportal infusion of hypothermic hydrogen-rich water solution on hepatic warm ischemia/reperfusion injury in rat model.
What the Researchers Studied
The researchers studied with acute cerebral infarction.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 4% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 4% source-reported H₂ gas concentration. 4°C HRSS and 24°C HRSS administration alleviated plasma liver enzymes The activities of AST and ALT were significantly higher in rats exposed to hepatic I/R injury compared with Golshahi, et al.; Protective effect of intraportal infusion of hypothermic hydrogen-rich water solution on hepatic warm ischemia/reperfusion injury in rat model. The authors concluded that cai et al., indicated that the apoptosis of neurons in newborn rats induced by hypoxia and ischemia is inhibited by inhalation of H₂, as the ratio of Terminal-deoxynucleotidyl Transferase Mediated NickEnd Labeling (TUNEL) staining positive cells and the activity of caspase-3 and caspase-12 of the hippocampus and cortex was decreased (5) which was compatible with the authors' finding about decrease of the activity of caspase-3 in hypothermic HRSS administrated groups. It has been shown that hydrogen is able to increase the level of antioxidant enzymes such as superoxide dismutase and catalase or heme oxygenase-1 to protect the cell and suppress the disturbing effects of oxidative stress (11, 12, 58). The present study revealed that hypothermic hydrogen-rich water solution effectively protected the hepatic tissue against cellular injury and organ dysfunction through the mechanisms that decrease the effect of oxidative stress, inflammation, apoptosis and necrosis.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was with acute cerebral infarction. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 4% source-reported H₂ gas concentration.
Limitations and Safety
Reported limitations: Some limitations existed in the study; the researchers have not evaluated serum and/or tissue hydrogen levels befor e and after hypothermic HRSS intraportal injection and their evaluation can better the cause and effect of HRSS administration and its protective effect.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://bjvp.org.br/bjvp/article/download/228/222.