Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.
Ikuroh Ohsawa, Kiyomi Nishimaki, Kumi Yamagata, Masahiro Ishikawa, Shigeo Ohta · Biochemical and biophysical research communications · 2008
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This preclinical study evaluated hydrogen-rich water in mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined mice.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as the researchers have found that hydrogen (dihydrogen; h(2)) acts as an effective antioxidant to reduce oxidative stress [i. ohta, hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, nat.
What the Researchers Found
Atherosclerotic lesions were significantly reduced by ad libitum drinking of H(2)-water (p=0.0069) as judged by Oil-Red-O staining series of sections of aorta. Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. The oxidative stress level of aorta was decreased.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included the researchers have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.