Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway.
Qian Li, Yang Ang, Qing-Qing Zhou, Min Shi, Wei Chen, Yujie Wang, Pan Yu, Bing Wan, Wanyou Yu, Liping Jiang, Yadan Shi, Zhao Lin, Shaozheng Song, Manlin Duan, Yun Long, Qi Wang, Wentao Liu, Hongguang Bao · Journal of pharmaceutical analysis · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, 3 3.1 Mice were injected intraperitoneally with LPS, and the effects of CCH administration and 4% hydrogen inhalation were observed. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in mice. 3 3.1 Mice were injected intraperitoneally with LPS, and the effects of CCH administration and 4% hydrogen inhalation were observed.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Fifty-five mice were randomly divided into five groups: control, lipopolysaccharide (LPS) model, LPS + H₂, LPS + CC, and LPS + CCH, to observe the 7-day survival rate and body weight changes in each group. Similar to the grouping for the in vivo experiment, the in vitro study was divided into four groups: control, LPS, LPS + H₂ and H₂. Hydrogen was produced by the hydrogen cell incubator and was used for the cell experiments. 3 3.1 Mice were injected intraperitoneally with LPS, and the effects of CCH administration and 4% hydrogen inhalation were observed. The authors concluded that the results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation. CCH, similar to hydrogen, was protective in LPS-induced ARDS mice, and the mechanism by which CCH acted was largely dependent on released hydrogen instead of carrier CC. 4 the researchers further investigated that molecular hydrogen mediates the activation of Trx2, a key protein of oxidative stress.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.