cumulate oxidative damage over time due to post-mitotic cells. Thus, modulation of oxidative stress is essential to overcome these disorders. Molecular hydrogen (H 2) has great potential for treating various diseases and
Keywords: Hematin, hydroxyl radical, molecular hydrogen, Nrf2, oxidative stress, porphyrin · Aging Pathobiology and Therapeutics · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, at the same time, H₂ can reduce the oxidized porphyrin with Fe(III) to restore heme, the reduced form of Fe(II). The authors concluded that it is concluded that the activation of Nrf2 is involved in one of the H₂ functions. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. At the same time, H₂ can reduce the oxidized porphyrin with Fe(III) to restore heme, the reduced form of Fe(II).
What the Researchers Studied
The study used a laboratory experiment. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 3% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 3% source-reported H₂ gas concentration. At the same time, H₂ can reduce the oxidized porphyrin with Fe(III) to restore heme, the reduced form of Fe(II). The authors concluded that it is concluded that the activation of Nrf2 is involved in one of the H₂ functions. In 2016, H₂ gas BRIEF Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted por- phyrin Shigeo Ohta a, b, * a Department of Neurology Medicine, Juntendo University, Graduate School of Medicine, Tokyo, 113-8421, Japan. b Department of Cell Biology, Graduate School of Medicine, Nippon Medical University, Tokyo, 113-8602, Japan.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a laboratory experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 3% source-reported H₂ gas concentration.
Limitations and Safety
Safety information: In 2014, the researchers Food Drug Administration (FDA) approved H₂ as generally recognized as safe (GRAS), allowing hydrogen- infused water to be marketed as a drink. The most important feature of H₂ gas inhalation therapy is that it is non-cytotoxic and safe for humans, as approved in Phase I clinical trial [47].
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at http://www.antpublisher.com/index.php/APT/article/download/566/692.