Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?
Sergej M Ostojic · Theranostics · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H₂), the youngest member of medical gases family with selective anti-oxidative properties.
What Effects Did Molecular Hydrogen Have?
A preliminary study demonstrated that H₂ is permeable to cell membranes and can protect mitochondria (and nuclei) from acute oxidative stress 3. As expected, the favorable effects of H₂ were abolished by ghrelin receptor antagonist (D-Lys 3 GHRP-6), implying GHRL and ghrelin receptor (GHS-R1α) as significant mediators of H₂ action. More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H₂), the youngest member of medical gases family with selective anti-oxidative properties. The authors concluded that however, recent studies suggest that H₂ may tackle other mitochondrial processes besides oxidative stress, including metabolic pathways that drive cellular energy.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.