Effect of hydrogen-rich water on acute peritonitis of rat models.
Jingyao Zhang, Qifei Wu, Sidong Song, Yong Wan, Ruiyao Zhang, Minghui Tai, Chang Liu · International immunopharmacology · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In male Sprague Dawley rats, three models showed the same result that hydrogen-rich water had an efficient protective effect on acute peritonitis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in male Sprague Dawley rats. Three models showed the same result that hydrogen-rich water had an efficient protective effect on acute peritonitis.
What the Researchers Studied
The researchers studied male Sprague Dawley rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
3 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not reported in the available source text, so H2HUBB did not estimate milligrams of H₂; reported treatment duration: 7 days. Three models showed the same result that hydrogen-rich water had an efficient protective effect on acute peritonitis. The authors concluded that hydrogen-rich water could alleviate the severity of acute peritonitis, and it might perform this function by its anti-inflammation, anti-oxidation and anti-bacterial effects and reducing NF-κB expression in the peritoneum tissues.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male Sprague Dawley rats. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. H2HUBB translates the reported hydrogen dose as 3 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not reported in the available source text, so H2HUBB did not estimate milligrams of H₂. The reported treatment duration was 7 days.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.