Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects.
Rafael Timón, Guillermo Olcina, Adrian González-Custodio, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Ismael Martínez Guardado · Biology of sport · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 1 trained participants, after HRW intake, only trained cyclists improved their performance in the anaerobic test with an increase in peak power (from 766.2 ± 125.6 to 826.5 ± 143.4 W; d =.51) and mean power (from 350.0 ± 53.5 to 380.2 ± 71.3 W; d =.51), and a decrease in the fatigue index (from 77.6 ± 5.8 to 75.1 ± 5.9%; d =.45). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 1 trained participants. After HRW intake, only trained cyclists improved their performance in the anaerobic test with an increase in peak power (from 766.2 ± 125.6 to 826.5 ± 143.4 W; d =.51) and mean power (from 350.0 ± 53.5 to 380.2 ± 71.3 W; d =.51), and a decrease in the fatigue index (from 77.6 ± 5.8 to 75.1 ± 5.9%; d =.45).
What the Researchers Studied
The researchers studied 1 trained participants. The study used a double-blind, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 1.9 mg/L H₂; Source-reported hydrogen exposure: 320 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. After HRW intake, only trained cyclists improved their performance in the anaerobic test with an increase in peak power (from 766.2 ± 125.6 to 826.5 ± 143.4 W; d =.51) and mean power (from 350.0 ± 53.5 to 380.2 ± 71.3 W; d =.51), and a decrease in the fatigue index (from 77.6 ± 5.8 to 75.1 ± 5.9%; d =.45). The authors concluded that the beneficial effects of HRW are mediated by the training status of athletes. Although the molecular mechanisms involved in the efficacy of HRW have to be further investigated, ingesting this type of water seems to have an anti-fatigue effect, suppressing the reduction in biological antioxidant potential, increasing lactate dehydrogenase and glutathione peroxidase activity, and scavenging cytotoxic ROS [ 7, 19, 31 ].
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a double-blind, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 1 trained participants. The reported sample size was 7. The study used a double-blind, placebo-controlled, crossover human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 1.9 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.