Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model.
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Tyler W LeBaron, Snait Tamir · World journal of gastroenterology · 2018
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Independent study record
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H2HUBB TAKEAWAY
In mice, compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass (46% vs 61%), an increase in lean body mass (42% vs 28%), and a decrease in hepatic lipid accumulation. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.
How Molecular Hydrogen Was Used
A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen (H₂) in EAW.
What the Researchers Found
EAW had several properties important to the study: (1) pH = 11; (2) oxidation-reduction potential of -495 mV; and (3) H₂ = 0.2 mg/L. the researchers evaluated the effects of RW and low and high HRW concentrations (L-HRW = 0.3 mg H₂/L and H-HRW = 0.8 mg H₂/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass (46% vs 61%), an increase in lean body mass (42% vs 28%), and a decrease in hepatic lipid accumulation (P < 0.01).
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that H₂ is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice.