Effects of hydrogen as adjuvant treatment for unstable angina.
Yanhong Si, Hua Tian, Bingqing Dong, Ying Zhang, Yuanyuan Wen, Xiubin Jia, Ying Li, Aihua Zhang, Shucun Qin · Experimental biology and medicine (Maywood, N.J.) · 2021
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Independent study record
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H2HUBB TAKEAWAY
In The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo, serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo.
Laboratory Model
The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo.
How Molecular Hydrogen Was Used
The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway. Clinical analysis showed hydrogen-rich water intake relieved angina symptoms in unstable angina patients.
What Molecular Hydrogen Changed
Serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment.
H₂ Mechanisms / Biological Findings
An atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent.
Authors’ Conclusion
The authors concluded that an atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway.