Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
John Sieh Dumbuya, Siqi Li, Lili Liang, Yanchen Chen, Jiang Du, Qiyi Zeng · Journal of translational medicine · 2022
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H2HUBB TAKEAWAY
In a laboratory model, eLISA analysis showed decreased TNF-α and IL-1β and increased IL-10 expression levels in the HRS-treated group. The authors concluded that these data demonstrated that HRS can improve survival rate, attenuate neuroinflammation, astrocyte and microglial activation, neuronal injury and mitochondrial dysfunction in juvenile SAE rat model, making it a potential therapeutic candidate in treating paediatric SAE. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
Here the researchers report the protective effect of hydrogen-rich saline in juvenile SAE rat model and its possible underling mechanism(s).
How Molecular Hydrogen Was Used
Rats were challenged with lipopolysaccharide (LPS) at a dose of 8 mg/kg injected intraperitoneally to induce sepsis and hydrogen-rich saline (HRS) administered 1 h following LPS induction at a dose of 5 ml/kg.
What Molecular Hydrogen Changed
ELISA analysis showed decreased TNF-α and IL-1β and increased IL-10 expression levels in the HRS-treated group.
Proposed Mechanism
Molecular hydrogen (H₂) has been reported to play crucial role in regulating inflammatory responses, neuronal injury, apoptosis and mitochondrial dysfunction in adult models of SAE. Here the researchers report the protective effect of hydrogen-rich saline in juvenile SAE rat model and its possible underling mechanism(s).
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.