Effects of Hydrogen-Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress.
Buket Boğa Kuru, Mustafa Makav, Mushap Kuru, Şükran Yediel Aras, Ebru Karadağ Sarı, Menekşe Bulut, Duried Alwazeer, Fikret Bektaşoğlu, Mükremin Ölmez, Turgut Kırmızıbayrak, Tyler W LeBaron · Veterinary medicine and science · 2025
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Independent study record
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H2HUBB TAKEAWAY
In rats, oxidant status in biochemical analyses decreased in the stress + HRW group compared to the stress group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
This study investigated the impact of drinking hydrogen-rich water (HRW) on growth performance, organ weights, thiol/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as the eight groups (each group [male/female] eight rats) comprised two control, two hydrogen, two stress and two stress + hydrogen.
What the Researchers Found
Oxidant status in biochemical analyses decreased in the stress + HRW group compared to the stress group.
H₂ Mechanisms / Biological Findings
This study investigated the impact of drinking hydrogen-rich water (HRW) on growth performance, organ weights, thiol/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.
Authors’ Conclusion
The authors concluded that the stress-related physiological parameters were reduced in the HRW + stress group compared to the stress group. HRW could be suggested when the organism is found in stressful conditions.