Emerging mechanisms and novel applications of hydrogen gas therapy.
Nathanael Matei, Richard Camara, John H Zhang · Medical gas research · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. 27 Lastly, HS by intravitreal (20 μL of 400 mL saline solution with hydrogen greater than 0.6 mM) and intraperitoneal (5 mL/kg) routes reduced retinal excitotoxic injury and promoted retinal recovery by the inhibition of glial cells, decreased expression of inducible NO synthase (iNOS) and 78 kDa glucose-regulated protein (GRP78), and increased clearance of glutamate. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. 27 Lastly, HS by intravitreal (20 μL of 400 mL saline solution with hydrogen greater than 0.6 mM) and intraperitoneal (5 mL/kg) routes reduced retinal excitotoxic injury and promoted retinal recovery by the inhibition of glial cells, decreased expression of inducible NO synthase (iNOS) and 78 kDa glucose-regulated protein (GRP78), and increased clearance of glutamate.
What the Researchers Studied
The authors reviewed emerging mechanisms and novel applications of hydrogen gas therapy.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 4% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 4% source-reported H₂ gas concentration. 27 Lastly, HS by intravitreal (20 μL of 400 mL saline solution with hydrogen greater than 0.6 mM) and intraperitoneal (5 mL/kg) routes reduced retinal excitotoxic injury and promoted retinal recovery by the inhibition of glial cells, decreased expression of inducible NO synthase (iNOS) and 78 kDa glucose-regulated protein (GRP78), and increased clearance of glutamate. In angiogenic pathways, hydrogen's inhibition of cyclic guanosine monophosphate-degrading phosphodiesterase led to higher levels of cyclic guanosine monophosphate, activation of protein kinase, and angiogenesis; next, as hydrogen gas increased the levels of intracellular calcium, stimulated vascular endothelial growth factor increased nitric oxide production. Reports support the ability of hydrogen gas to downregulate the expression of pro-inflammatory cytokines and pro-apoptotic factors.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 4% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.