Evaluation of the Potential Use of Oxy-Hydrogen Gas for the Treatment of Lactococcus garvieae Infected- Zebrafish in Hydrogen-Rich Water Aquarium
Önalan, Şükrü, Bulut, Menekşe, Alwazeer, Duried · Brazilian Archives of Biology and Technology · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The authors found that HRW treatment had a significantly decreased trend on the IL-1β and IL-6 expression levels in A. hydrophila – infected zebrafish compared with the control. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how oxy-hydrogen gas inhalation was evaluated in this publication and summarizes the source-grounded findings below. The authors found that HRW treatment had a significantly decreased trend on the IL-1β and IL-6 expression levels in A. hydrophila – infected zebrafish compared with the control.
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 30% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 30% source-reported H₂ gas concentration. The authors found that HRW treatment had a significantly decreased trend on the IL-1β and IL-6 expression levels in A. hydrophila – infected zebrafish compared with the control. The authors concluded that sOD, both infected non-HRW group (G2) and infected 10% HRW(G3) and 20% HRW (G4) groups increased the gene expression of SOD but not infected 100% HRW (G5) ( Figure 5 ).
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment. The hydrogen delivery method was oxy-hydrogen gas inhalation. The source-reported hydrogen concentration was 30% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at http://www.scielo.br/j/babt/a/5tNpdKxHXKJ5DYwbgJBfHpm/?lang=en.