Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.
Yoshiharu Tanaka, Li Xiao, Nobuhiko Miwa · Medical gas research · 2022
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
At 0 to 120 minutes after they took a bath, the CRP level of the HW group was lower than that of the control group ( Figure 7C ), although no significant difference was found between the two groups, indicating that the hydrogen-rich water bath induces an anti-inflammatory activity in the human tissues. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338-682 μg/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 × 107/mL along with the increase of correlative dissolved hydrogen.
What Effects Did Molecular Hydrogen Have?
Note: A schematic illustration is hypothetically proposed for how hydrogen bubbles exert antioxidant activity in living cells, based on data in the present study. The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338-682 μg/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 × 107/mL along with the increase of correlative dissolved hydrogen. The authors concluded that hydrogen-rich water bath is considered to be more capable of promoting the anti-oxidative activity in the blood compared with oral administration and skin ointment for other antioxidants. This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum between healthy volunteers and inflammatory/collagen disease-patients. At 0 to 120 minutes after they took a bath, the CRP level of the HW group was lower than that of the control group ( Figure 7C ), although no significant difference was found between the two groups, indicating that the hydrogen-rich water bath induces an anti-inflammatory activity in the human tissues.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 6. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
Reported limitations: It is difficult to secure medium- to long-term cooperation among subjects with diseases; thus, the limitation of this study is to end in a case study.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.