Hydrogen gas (H 2), a colorless, tasteless, odorless, non-irritating and highly flammable diatomic gas, has been used in medical applications to prevent decomposition sickness in deep divers. For a long time, H2 was thought to be a “biologically inert gas” which could not
Hydrogen gas (H 2), a colorless, tasteless, odorless, non-irritating and highly flammable · 2007
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, the decrease in reperfusion damage improved long term neurological function, such as thermoregulation and weight maintenance, at one week, implying that hydrogen gas can protect cells in vivo. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. The decrease in reperfusion damage improved long term neurological function, such as thermoregulation and weight maintenance, at one week, implying that hydrogen gas can protect cells in vivo.
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 49% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 49% source-reported H₂ gas concentration. The decrease in reperfusion damage improved long term neurological function, such as thermoregulation and weight maintenance, at one week, implying that hydrogen gas can protect cells in vivo. The authors concluded that not solved problems of H₂ as a therapeutic agent First of all, as the researchers mentioned above, grow ing number of evidence suggest that ROS scavenging properties are unlikely to be the only explanation for the effects of hydrogen (Huang et al., 2010). Recent studies www.intechopen.com Oxidative Stress – Molecular Mechanisms and Biological Effects 140 showed that the main component of these gases is hydrogen, whose increase may contribute to the heart protective effect. Hydrogen gas directly an d violently reacts with oxidizing elements such as chlorine and fluorine and is highly flammable, a property evident in the 1937 www.intechopen.com Oxidative Stress – Molecular Mechanisms and Biological Effects 136 Hindenburg zeppelin fire and its use as propellant fuel for the space shuttle.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 49% source-reported H₂ gas concentration.
Limitations and Safety
Safety information: However, much additional research is required prior to verification, such as characterizing the molecular mechanism of hydrogen’s effects. for H₂ administration 5.1 Inhalation For a long time, hydrogen inhalation has been applied in deep diving to prevent decompression sickness and nitrogen narcosis, in which an exotic, breathing gas mixture of 49% hydrogen, 50% helium and 1% oxygen is researchers ed (Abraini et al., 1994), so the safety of hydrogen for humans is fully proved. Ho wever, safety is a big concern in hydrogen inhalation. a suit of complex apparatus is required for safety, and a strict operating rule mu st be developed to guarantee the safety of hydrogen inhalation.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://api.intechopen.com/chapter/pdf-download/35987.pdf.