Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway.
Qiang Xie, Xue-Xiang Li, Peng Zhang, Jin-Cao Li, Ying Cheng, Yan-Ling Feng, Bing-Sheng Huang, Yu-Feng Zhuo, Guo-Hua Xu · Molecular medicine reports · 2014
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, when the cells were exposed to SGD, levels of intracellular ·OH free radicals were markedly increased; this was mitigated by H₂ gas‐rich medium. The authors concluded that in conclusion, H₂ gas protected cardiomyocytes from ischemia‐induced myocardial injury through elimination of ·OH free radicals and also through activation of the Nrf2/HO‐1 signaling pathway. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
What Molecular Hydrogen Changed
When the cells were exposed to SGD, levels of intracellular ·OH free radicals were markedly increased; this was mitigated by H₂ gas‐rich medium.
Proposed Mechanism
Hydrogen (H₂) gas, as a water‐ and lipid‐soluble small molecule, is not only able to selectively eliminate hydroxyl (·OH) free radicals, but also to enhance endogenous antioxidative defense systems in rat lungs and arabidopsis plants.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.