Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats.
Kentaro Noda, Norihisa Shigemura, Yugo Tanaka, Jay Bhama, Jonathan D'Cunha, Hirosuke Kobayashi, James D Luketich, Christian A Bermudez · Transplantation · 2014
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Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. The authors concluded that preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory changes, promoted mitochondrial biogenesis in the lungs throughout the procedure, and resulted in better posttransplant graft function. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production.
What the Researchers Studied
The study used a laboratory experiment.
What Effects Did Molecular Hydrogen Have?
This study examined proinflammatory events and metabolic profiles in lung grafts on EVLP and tested whether preconditioning lung grafts with inhaled hydrogen, a potent, cytoprotective gaseous signaling molecule, would alter the lungs’ response to EVLP. Preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory changes, promoted mitochondrial biogenesis in the lungs throughout the procedure, and resulted in better posttransplant graft function. Hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. Hydrogen administration attenuated proinflammatory changes during EVLP through upregulation of the heme oxygenase-1.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://journals.lww.com/transplantjournal/abstract/10.1097/tp.0000000000000254~hydrogen-preconditioning-during-ex-vivo-lung-perfusion?redirectionsource=fulltextview.