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Human clinical evidenceHuman Clinical Studyhydrogen-rich water

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial.

Liren Qian, Miao Liu, Jianliang Shen, Jian Cen, Defeng Zhao · Frontiers in immunology · 2020

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Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Human clinical evidence
Publication type Human Clinical Study
Hydrogen method hydrogen-rich water

H2HUBB TAKEAWAY

In 24 patients, no significant toxicity was observed. This open-label study supports molecular hydrogen's therapeutic potential for the condition studied, while larger randomized, placebo-controlled studies are needed to confirm the finding.

What the Researchers Studied

24 patients

How the Study Was Conducted

Human clinical study

How Molecular Hydrogen Was Used

Patients received hydrogen-rich water 4ml/kg orally three times a day.

What the Researchers Found

No significant toxicity was observed.

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Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas can ameliorate seizure burden during therapeutic hypothermia in asphyxiated newborn piglets.

Toui Tsuchiya, Shinji Nakamura, Yuichiro Sugiyama, Yasuhiro Nakao, Tsutomu Mitsuie, Kota Inoue, Eri Inoue, Yinmon Htun, Makoto Arioka, Kenichi Ohta, Hirosuke Morita, Noriko Fuke, Sonoko Kondo, Kosuke Koyano, Takanori Miki, Masaki Ueno, Takashi Kusaka · Pediatric research · 2024

In an animal model, the percentage of piglets with an abnormal aEEG background (aEEG-BG), abnormal aEEG-BG+Sz and SE was lower with TH + H₂ than with TH at 24 h after HI insult. These…

Primary topic
Molecular Hydrogen Overview
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1038/s41390-024-03041-6
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Laboratory or cellular evidenceLaboratory StudyOther or not reported

MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.

Bing Han, Haoxin Zhou, Guang Jia, Yongwei Wang, Zengfu Song, Gang Wang, Shangha Pan, Xuewei Bai, Jiachen Lv, Bei Sun · The FEBS journal · 2016

In a laboratory model, the subsequent in vitro experiments showed that H₂ treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-κB and the expression…

Primary topic
Molecular Hydrogen Overview
Delivery method
Other or not reported
Main limitation
Laboratory findings may not translate directly to living organisms or clinical outcomes.
Study ID
DOI: 10.1111/febs.13629
View Study View Source
Preclinical animal evidenceAnimal studyhydrogen-rich water

Mechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.

Mengya Liu, Yong Wang, Yuhao Wang, Huan Liu, Jianhua Li, Jianguo Li, Xiujun Qin · Molecular and cellular biochemistry · 2025

The results of the Morris water maze test showed that compared with the IR group, the escape latency of the rats in the IR + LHRW group and the IR + HHRW group was…

Primary topic
Molecular Hydrogen Overview
Delivery method
hydrogen-rich water
Study ID
DOI: 10.1007/s11010-025-05350-8
View Study View Source