Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.
Kaibori M, Kosaka H · Trials · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This record describes a planned hydrogen study; no treatment result is available yet.
Oxyhydrogen hydrogen research study 2021: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. Molecular hydrogen had been considered inactive in vivo but is an antioxidant that selectively reduces highly toxic reactive oxygen species (ROS, chemically reactive molecules that can damage cells when excessive) (ROS). Animal studies have reported that hydrogen gas inhalation helped alleviate cerebral and cardiac ischemia-reperfusion injuries. In humans, hydrogen inhalation therapy is presently approved as a treatment under Advanced Medical Care B in Japan (jRCTs031180352: limited to adult patients who suffered out-of-hospital cardiac arrest and are in a continuous coma) and its effectiveness is being examined in a clinical trial.
Publication: Kaibori M, Kosaka H, Trials, 2021.
What the researchers studied
The primary endpoint is patient QOL (score of a 40-item quality of recovery questionnaire, QoR40) on postoperative day 3 and the secondary endpoints are…
What effects did molecular hydrogen have?
No treatment effects have been reported yet. This publication describes a planned study rather than completed results.
Why these findings matter
This publication describes how a study is planned. It cannot yet support a conclusion about hydrogen’s therapeutic potential because completed results have not been reported.
How strong is this evidence?
This is a study protocol, so no completed outcome evidence is available yet. Randomization: Yes. Blinding: Double-blind.
Technical study details
- Publication type: Study protocol
- Evidence type: Protocol or ongoing research
- Research model or population: Human participants
- Randomized: Yes
- Blinding: Double-blind
- Hydrogen method: Oxyhydrogen
Limitations and safety
Important limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety information: The abstract did not provide detailed safety or adverse-event information.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.