Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway.
Jing Wang, Xiang-Jian Zhang, Yuan-Yuan Du, Guang Shi, Cong-Cong Zhang, Rong Chen · Acta neurobiologiae experimentalis · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, the infarct volume of mice in the hydrogen-rich saline‐H group decreased significantly compared to that of the distal middle cerebral artery occlusion (dMCAO) group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
In the in vitro experiment, compared with the oxygen‐glucose deprivation (OGD) group, the active oxygen content in the 75% HRM group decreased, and the mitochondrial membrane potential and adenosine triphosphate (ATP) content increased. The infarct volume of mice in the HRS‐H group decreased significantly compared to that of the distal middle cerebral artery occlusion (dMCAO) group. Compared to the dMCAO group, the activity of superoxide dismutase (SOD) and the level of glutathione (GSH) significantly increased in the HRS‐H group. Compared with the dMCAO group, the number of apoptotic cells in the HRS‐H group decreased.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included this study explored the protective effect and mechanism of hydrogen‐rich saline (HRS) on the neurological function of mice with cerebral ischemia.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.