Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
Xiao Zhai, Xiao Chen, Jiancan Lu, Yaping Zhang, Xuejun Sun, Qin Huang, Qijin Wang · Molecular medicine reports · 2017
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, serum levels of (E) FBG and (F) FINS. (G) Results of the ISI and HOMA -IR measurements. (I) Insulin tolerance test; after insulin administration, blood glucose gradually decreased. (J) Glucose tolerance test; after glucose intake, blood glucose gradually increased and reached its peak at 30 min and then decreased. *P<0.05 vs. control and H₂ groups; **P<0.01 vs. control and H₂ groups. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in rats. Serum levels of (E) FBG and (F) FINS. (G) Results of the ISI and HOMA -IR measurements. (I) Insulin tolerance test; after insulin administration, blood glucose gradually decreased. (J) Glucose tolerance test; after glucose intake, blood glucose gradually increased and reached its peak at 30 min and then decreased. *P<0.05 vs. control and H₂ groups; **P<0.01 vs. control and H₂ groups.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Kajiyama et al (12) demonstrated that in patients with T2DM, intake of H₂-rich water was associated with significant decreases in the levels of modified low‑density lipoprotein (LDL) cholesterol, small dense LDL and urinary 8-isoprostanes by 15.5, 5.7 and 6.6%, respectively, and concluded that supplementation with H₂-rich water may have a beneficial role in the prevention and treatment of T2DM and insulin resistance. Serum levels of (E) FBG and (F) FINS. (G) Results of the ISI and HOMA -IR measurements. (I) Insulin tolerance test; after insulin administration, blood glucose gradually decreased. (J) Glucose tolerance test; after glucose intake, blood glucose gradually increased and reached its peak at 30 min and then decreased. *P<0.05 vs. control and H₂ groups; **P<0.01 vs. control and H₂ groups. The authors concluded that in conclusion, H₂‑rich saline may significantly improve NAFLD, possibly by reducing oxidative stress and activating hepatic PPARα and PPARγ expression. Molecular hydrogen (H₂) may ameliorate oxidative stress injuries by selectively neutralizing peroxynitrite and hydroxyl radicals.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.spandidos-publications.com/10.3892/mmr.2017.6120/download.