Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice.
Qu Liu, Bao-Shan Li, Yu-Jiao Song, Ming-Gen Hu, Jian-Yue Lu, Ang Gao, Xue-Jun Sun, Xi-Ming Guo, Rong Liu · Molecular medicine reports · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, treatment with HS reduced the levels of these markers and alleviated morphological defects in the mitochondria following injury. The authors concluded that in conclusion, HS attenuates mitochondrial oxidative stress and dysfunction, and inhibits mitochondrial-mediated apoptosis in the livers of BDL mice. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
Laboratory experiment
What Molecular Hydrogen Changed
Treatment with HS reduced the levels of these markers and alleviated morphological defects in the mitochondria following injury.
Proposed Mechanism
Previous studies have demonstrated that hydrogen-rich saline (HS) protects against bile duct ligation (BDL)-induced liver injury by suppressing oxidative stress and inflammation.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.