Protective effect of hydrogen-rich saline on decompression sickness in rats.
Xiao-Xiao Ni, Zhi-Yu Cai, Dan-Feng Fan, Yun Liu, Rong-Jia Zhang, Shu-Lin Liu, Zhi-Min Kang, Kan Liu, Run-Ping Li, Xue-Jun Sun, Wei-Gang Xu · Aviation, space, and environmental medicine · 2011
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Hydrogen-rich saline reduced decompression-sickness incidence and associated lung and spinal-cord injury markers in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined male Sprague-Dawley rats.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
H₂-rich saline significantly decreased the incidence of DCS from 67.57 to 35.14% and partially counteracted the increases in the total concentration of protein in the bronchoalveolar lavage from 0.33 +/- 0.05 to 0.14 +/- 0.01 mg x ml(-1) (mean +/- SD; P < 0.05), myeloperoxidase activity from 0.86 +/- 0.16 to 0.44 +/- 0.13 U/g, levels of malondialdehyde (MDA) from 0.80 +/- 0.10 to 0.48 +/- 0.05 nmol x mg(-1), 8-hydroxydeoxyguanosine from 253.7 +/- 9.3 to 191.2 +/- 4.8 pg x mg(-1) in the lungs, and MDA level from 1.77 +/- 0.20 to 0.87 +/- 0.23 nmol x mg(-1) in the spinal cord in rat DCS models. The histopathology results also showed that H₂-rich saline ameliorated DCS injuries.
H₂ Mechanisms / Biological Findings
INTRODUCTION: Hydrogen (H₂) has been reported to be effective in the treatment of oxidative injury, which plays an important role in the process of decompression sickness (DCS).
Authors’ Conclusion
The authors concluded that it is concluded that H₂-rich saline may have a protective effect against DCS, possibly due to its antioxidant action.